HNF1A - Hepatic Nuclear Factor 1 Alpha

HNF1A (Hepatic Nuclear Factor 1 Alpha) is a gene which acts as a switch that turns on and off other genes in the body. Changes in the HNF1A gene cause diabetes by lowering the amount of insulin that is produced by the pancreas. It allows insulin to be produced normally in childhood but the amount of insulin reduces as you get older. HNF1A is one of a group of familial types of diabetes called maturity onset diabetes of the young (MODY). HNF1A accounts for 70% of MODY cases.

More information about diabetes caused by changes in the HNF1A gene, and how this type of diabetes can be treated is available on the diabetesgenes.org website. Please follow the link below.

HNF1A Diabetes and Treatment